This multidrug-resistant bacteria, which poses a specific danger to patients in hospitals and those whose care needs devices like ventilators and blood catheters, is described by the World Health Organisation as being particularly dangerous.
According to the latest research that was published on Thursday in the scientific journal Nature Chemical Biology, the researchers are from the Massachusetts Institute of Technology and McMaster University, as per the Guardian.
"These bacteria have built-in abilities to find new ways to resist treatment and can pass along genetic material that allows other bacteria to become drug-resistant as well," said the WHO.
Patients who have open surgical incisions are at high risk for infection from Acinetobacter baumannii. The Acinetobacter genus of bacteria (germs) is frequently found in the environment, such as in soil and water, according to the Centres for Disease Control and Prevention (CDC). Acinetobacter baumannii can infect wounds in various areas of the body, as well as the blood, urinary system, and lungs (pneumonia).
A graduate student from MacMaster University, Gary Liu, said, "We had a whole bunch of data that was just telling us about which chemicals were able to kill a bunch of bacteria and which ones weren’t. My job was to train this model, and all that this model was going to be doing is telling us essentially if new molecules will have antibacterial properties or not."
"Then basically through that, we’re able to just increase the efficiency of the drug discovery pipeline and … hone in all the molecules that we really want to care about," he added.
"Using AI, we can rapidly explore vast regions of chemical space, significantly increasing the chances of discovering fundamentally new antibacterial molecules," he said adding, "We know broad-spectrum antibiotics are suboptimal and that pathogens have the ability to evolve and adjust to every trick we throw at them … AI methods afford us the opportunity to vastly increase the rate at which we discover new antibiotics, and we can do it at a reduced cost. This is an important avenue of exploration for new antibiotic drugs," said Jonathan Stokes, an assistant professor.